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Distant metastases form monophyletic groups and have reduced clonality compared to LN metastases, suggesting different evolutionary mechanisms between LN metastases and distant metastases (154)

The predicted N-terminal domain structure of HrGSTm1 was , a thioredoxin structure with G-site, which is consistent with McGST1 of Mytilus coruscus and CsGSTM1 of Clonorchis sinensis [14,15,16]

This suggests the PHB-ANXA2 system has multiple roles in fat biology, and FTPP may be affecting more pathways than just the obvious vascular destruction